PE-22-28
PE-22-28 5mg - Image 2

PE-22-28 5mg

£22.90
  • Batch HPLC tested at 99%+ purity.
  • Store frozen long term or in fridge when ready to be used.
  • 20% off purchases of ten or more.
  • Sold for research purposes only.
  • Contact us for Wholesale Orders.

 

Download COA here: PE-22-28 COA.pdf
Please note if you have a different Batch ID please contact us for the latest COA.

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PE-22-28

PE-22-28 is a synthetic derivative of the naturally occurring peptide spadin. Spadin is a secreted peptide derived from sortilin. It is an antagonist of the TREK-1 (-MIK-related-potassium channel) receptor, a two-pore potassium channel identified as a potential target in the treatment of depression and as a possible neurogenic regulator. Early studies in mice have shown that a deletion of the TREK-1 receptor makes them resistant to depression. Similarly, treatment with sortilin leads to resistance to depression boosts the growth of both neurons and the synaptic interconnections between neurons.

Interestingly, shortened analogs of spadin actually show better TREK-1 inhibition than spadin itself PE-22-28 is the representative peptide for this group of synthetic spadin analogs. PE-22-28 has been shown to be more stable and have improved antidepressant activity and neurogenic properties over the naturally occurring spadin.

TREK-1, which is primarily found in the brain, is also found in the heart, smooth muscle cells, lung tissue, the prostate, and in specific areas of the pancreas. Though it has been primarily studied as a target for antidepressant activity, TREK-1 plays important roles in pain perception; anesthesia, and neuroprotection. These properties have made TREK-1 a major research target in academia and industry.

Keywords: PE-22-28, PE22-28, PE2228.

87 reviews for PE-22-28 5mg

  1. Cornelia L. –

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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

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