TB-500
TB-500 5mg - Image 2

TB-500 5mg

£21.90
  • Batch HPLC tested at 99%+ purity.
  • Store frozen long term or in fridge when ready to be used.
  • 20% off purchases of ten or more.
  • Sold for research purposes only.
  • Contact us for Wholesale Orders.

 

Download COA here: TB-500 COA.pdf
Please note if you have a different Batch ID please contact us for the latest COA.

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TB-500

TB-500 (Thymosin beta-4) is a protein that in humans is encoded by the TMSB4X gene.[1][2][3] 

The protein consists (in humans) of 43 amino acids (sequence: SDKPDMAEI EKFDKSKLKK TETQEKNPLP SKETIEQEKQ AGES) and has a molecular weight of 4921 g/mol.[4]

Thymosin-β4 is a major cellular constituent in many tissues. Its intracellular concentration may reach as high as 0.5 mM.[5] Following Thymosin α1, β4 was the second of the biologically active peptides from Thymosin Fraction 5 to be completely sequenced and synthesized.[6]

This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y (TMSB4Y).[3]

Thymosin β4 was initially perceived as a thymic hormone. However this changed when it was discovered that it forms a 1:1 complex with G (globular) actin, and is present at high concentration in a wide range of mammalian cell types.[6] When appropriate, G-actin monomers polymerize to form F (filamentous) actin, which, together with other proteins that bind to actin, comprise cellular microfilaments. Formation by G-actin of the complex with β-thymosin (= “sequestration”) opposes this.

References
  1. Gómez-Márquez J, Dosil M, Segade F, Bustelo XR, Pichel JG, Dominguez F, Freire M (Oct 1989). “Thymosin-beta 4 gene. Preliminary characterization and expression in tissues, thymic cells, and lymphocytes”. Journal of Immunology. 143 (8): 2740–4. doi:10.4049/jimmunol.143.8.2740. PMID 2677145.
  2. Lahn BT, Page DC (Oct 1997). “Functional coherence of the human Y chromosome”. Science. 278 (5338): 675–80. Bibcode:1997Sci…278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
  3. “Entrez Gene: TMSB4X thymosin, beta 4, X-linked”.
  4. “protein NP_066932”. NCBI.
  5. Hannappel E (September 2007). “beta-Thymosins”. Annals of the New York Academy of Sciences. 1112 (1): 21–37. Bibcode:2007NYASA1112…21H. doi:10.1196/annals.1415.018. PMID 17468232. S2CID 222082792.
  6. Safer D, Elzinga M, Nachmias VT (March 1991). “Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable”. J. Biol. Chem. 266 (7): 4029–32. doi:10.1016/S0021-9258(20)64278-8. PMID 1999398.

 

Keywords: TB-500, TB500, Thymosin beta-4.

325 reviews for TB-500 5mg

  1. Karen –

    Exceeded my expectations.

  2. Kirsten Stewart –

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  3. Anonymous –

    Happy customer.

  4. Sam Morris –

    ItÕs fantastic.

  5. Esme P. –

    This is amazing quality.

  6. Richard H. –

    Beyond my expectations.

  7. Linda W. –

    Received it so fast, thank you!

  8. Stephanie –

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  9. Sue M. –

    IÕm really let down by this product.

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    Outstanding product.

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  12. Sasha –

    IÕve had faster deliveries from other places.

  13. Samantha –

    CouldnÕt ask for more.

  14. Dave Ashdown –

    Love everything about it.

  15. Antonia A. –

    Incredibly useful.

  16. adam clarke –

    Happy with this purchase.

  17. Heidi Banks –

    Super fast delivery, no issues at all.

  18. Jenny Laidlaw –

    Really dissatisfied with this.

  19. Fanni F. –

    Took way too long to arrive.

  20. Jennifer Hughes –

    Fantastic product.

  21. Sarah C. –

    Delivers as promised.

  22. Anonymous –

    Very functional.

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    CouldnÕt be happier.

  27. Matthew M. –

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  28. Heidi Banks –

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  29. Anonymous –

    Took forever to ship.

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  34. Emma Mullins –

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  36. Fiona H. –

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  55. Laura H. –

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  56. Mark Andrews –

    Frustrated with how slow the shipping was.

  57. Matthew –

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  59. Anonymous –

    Not impressed with the shipping speed.

  60. Kiren –

    Excellent choice.

  61. Emma Hartwell –

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  62. Vince Chiappinelli –

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  64. Lauren S. –

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  65. SARAH LEADSOM –

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  70. Dulcie R. –

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  71. Matthew Gray –

    Brilliant value.

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  73. Verified Buyer –

    ItÕs perfect for me.

  74. Edmund N. –

    Beyond satisfied.

  75. Verified Buyer –

    Not worth the price tag.

  76. Claire –

    Fast delivery, product is perfect.

  77. Mark Underhill –

    ItÕs exactly what I needed.

  78. Ange Perrett –

    Super happy with my decision.

  79. Jane Runnett –

    Absolutely fantastic.

  80. Mx P M Kitcher –

    IÕm loving this product.

  81. Ann A. –

    Does what itÕs supposed to.

  82. George Varnes –

    Very happy with this.

  83. Manjit –

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  84. Amy Prescott –

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  85. Fiona Stone –

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  89. Andrea G. –

    Highly recommend.

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  93. Robyn –

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  94. Anonymous –

    Great performance.

  95. Claire K. –

    Product is fine, but the delivery was a joke.

  96. Caroline –

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  97. Laura R. –

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  98. Emma –

    IÕm really pleased with this.

  99. Charlotte –

    Love the ease of use.

  100. Joanne N. –

    Delivery was quicker than anticipated.

  101. Sydney King –

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  102. Karen Hall –

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  103. Nick M. –

    Perfect for my needs.

  104. Paul F. –

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  105. Sarah C. –

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  106. Anonymous –

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  107. Anonymous –

    A total game-changer.

  108. Carla –

    Top quality.

  109. Anna –

    ItÕs fantastic.

  110. Anonymous –

    Arrived fast, very pleased.

  111. MORAG R. –

    Came quickly, very happy with it.

  112. Anonymous –

    Fast delivery, exceeded my expectations.

  113. Nicola B. –

    ItÕs everything I wanted.

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    Fast delivery and works great.

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    Came so fast, amazing service.

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  126. Anonymous –

    For this price, it should be better.

  127. Shirley Tregonning –

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  128. Margot C. –

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  129. Wayne Cross –

    Wasn’t happy with how long it took.

  130. Matthew C. –

    Delivery took way too long to be acceptable.

  131. Sophie –

    Why did it take so long to ship?

  132. Anonymous –

    Not worth the wait, considering the shipping time.

  133. Simon Proctor –

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  134. Janet –

    Wasn’t impressed with the slow delivery.

  135. Jeanette –

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  137. Gemma –

    Delivery speed was awful.

  138. Tim D. –

    Not worth the wait.

  139. Nicola Paling –

    Shipping took way too long.

  140. Anonymous –

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  141. Georgina –

    Way too slow, wonÕt order again.

  142. Grace –

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  143. Jude H. –

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  144. Anonymous –

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  145. Patricia Price –

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  147. Emma A. –

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  149. Jack Richards –

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    Love the results.

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    Love everything about it.

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    The best IÕve seen.

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    Does the trick.

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  232. Natasha –

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    Fantastic performance.

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    So pleased with this purchase.

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    Amazing product.

  237. Sara Lincoln –

    Does exactly what it says.

  238. Fatimah Z. –

    ItÕs fantastic.

  239. daniel –

    Works wonderfully.

  240. Debbie Edwards –

    CouldnÕt ask for more.

  241. Claire –

    Awesome quality.

  242. Natalie Green-Wood –

    ItÕs a lifesaver.

  243. Mel M. –

    Well worth it.

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    Very durable.

  245. Ida M. –

    I love this thing.

  246. Jade Blundell –

    CouldnÕt be happier.

  247. Heather Angell –

    Extremely satisfied.

  248. Vikki M. –

    ItÕs super reliable.

  249. Oliver Anthony –

    I highly recommend this.

  250. Susie –

    This is a must-have.

  251. Gabriella –

    Excellent quality product.

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    So pleased with this purchase.

  253. Caroline –

    Fast delivery and perfect product.

  254. Caroline –

    Arrived earlier than I thought.

  255. Aimee R. –

    Quick shipping and amazing service.

  256. Nick Morris –

    Speedy delivery, couldnÕt be happier.

  257. Anamaria V. –

    Arrived fast, very pleased.

  258. Andrew B. –

    Arrived fast, no complaints at all.

  259. Elaine Budd –

    Amazed by the quick delivery.

  260. Clare M. –

    Arrived much faster than I expected.

  261. Ashley Berrisford –

    Highly recommend.

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    Perfect purchase.

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    Great purchase.

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    High quality.

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    A great product.

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    I use it all the time.

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    Super happy with how it works.

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    Best quality IÕve had.

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    Love this item.

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    IÕm loving this product.

  274. Hugo Pinto –

    CouldnÕt be more satisfied.

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    Extremely happy with my choice.

  276. Michelle Cooke –

    Totally satisfied with this.

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    Exceeded my expectations.

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  279. Grace –

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    Totally satisfied.

  281. Catherine Flaherty –

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  283. Kirsty –

    Exceeded expectations.

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    Great purchase.

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  287. Emmalene White –

    Very durable.

  288. Tony Dove –

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  289. Sophie Palmer –

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  290. Lydia Anthony –

    Excellent quality.

  291. Steven –

    Super happy with the performance.

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  293. Janine –

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  294. Laura C. –

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  295. Lauren P. –

    Amazing value for money.

  296. Louise –

    Product arrived in no time.

  297. Kathy Bellworthy –

    Totally love it.

  298. Jessica A. –

    Love using this.

  299. Philippa Burnet –

    Does exactly what it says.

  300. Lisa Kaye –

    Amazing functionality.

  301. nicola w. –

    Great design and quality.

  302. David’s W. –

    Excellent value for money.

  303. Clareece –

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  304. Anonymous –

    The best IÕve seen.

  305. Gail-Marie –

    Very happy with my choice.

  306. Cristina Chirila –

    I highly recommend this.

  307. Stephen –

    This is a must-have.

  308. Ashley Hawkins –

    Absolutely love using it.

  309. Katie Fry –

    Fantastic performance.

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    Love it.

  312. Harry Wild –

    So glad I bought this.

  313. Seren C. –

    Perfect for my needs.

  314. Anonymous –

    IÕm very pleased.

  315. Tracy –

    It works beautifully.

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    IÕm amazed by how well this works.

  317. Helen Braithwaite –

    Quick shipping, great service.

  318. Laura P. –

    Fast delivery and works perfectly.

  319. Rachel –

    Arrived quickly, exactly what I wanted.

  320. Pauline M. –

    Great value.

  321. Lorraine Mckeown –

    IÕm obsessed.

  322. Anonymous –

    Highly satisfied.

  323. Miss S Hay –

    Incredibly useful.

  324. Luke Sullivan –

    Great bang for the buck.

  325. Mr Dean J Hay –

    As with all their products so far absolutely faultless.

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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

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