VIP 5mg

• OP Labs formerly Oxford Peptides.
• Batch HPLC tested at 99%+ purity.
• Store frozen long term or in fridge when ready to be used.
• Sold for research purposes only.
• Contact us for Wholesale Orders.

Download COA here: VIP COA.pdf
Please note if you have a different Batch ID please contact us for the latest COA.

VIP

Vasoactive Intestinal Peptide (VIP)

Chemical Identifiers

• IUPAC Name: (2S)-4-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-carboxypropanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylsulfanylbutanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoic acid
• Molecular Formula: C147H237N43O43S
• CAS Number: 17038-86-9
• PubChem CID: 16132300

Molecular Structure

Vasoactive Intestinal Peptide (VIP) is a 28-amino acid peptide, part of the glucagon/secretin superfamily. Its amino acid sequence is:

His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Cys-Gly-Thr-Pro-Gly-Ala-Gly-Glu-Glu-Gly-Gly-Gly-Gly-Gly-Gly-Gly-Gly

VIP adopts an alpha-helical structure stabilized by disulfide bonds between cysteine residues.

Gene and Protein Information

• Gene Symbol: VIP
• Gene ID: 7432 (NCBI Gene Database)
• Protein ID: P01282 (UniProt)
• Organism: Homo sapiens

Receptor Interaction

VIP binds to G protein-coupled receptors VPAC1 (VIPR1) and VPAC2 (VIPR2), expressed in various tissues including brain, lung, gastrointestinal tract, and immune cells. Binding induces increased intracellular cyclic AMP (cAMP) and downstream signaling pathways.

References

1. Vasoactive Intestinal Peptide. PubChem Compound Summary for CID 16132300. https://pubchem.ncbi.nlm.nih.gov/compound/Vasoactive-Intestinal-Peptide
2. UniProtKB – P01282 (VIP_HUMAN). https://www.uniprot.org/uniprotkb/P01282/entry
3. VIPR1 – Vasoactive Intestinal Polypeptide Receptor 1 – Homo sapiens (Human). UniProtKB. https://www.uniprot.org/uniprotkb/P32241/entry
4. VIPR2 – Vasoactive Intestinal Polypeptide Receptor 2 – Homo sapiens (Human). UniProtKB. https://www.uniprot.org/uniprotkb/P41587/entry
5. Vasoactive Intestinal Peptide. Wikipedia. https://en.wikipedia.org/wiki/Vasoactive_intestinal_peptide

Keywords: VIP, Vasoactive intestinal peptide.