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• Batch HPLC tested at 99%+ purity.
• Store frozen long term or in fridge when ready to be used.
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Download COA here: ARA-290 COA.pdf
Please note if you have a different Batch ID please contact us for the latest COA.

ARA-290

🔬 ARA‑290 (Cibinetide) — Technical Summary

Chemical Identity & Synonyms

• Name: ARA‑290 (Cibinetide)
• Synonyms: Pyroglutamate Helix B Surface Peptide (PH‑BSP), pHBSP
• CAS Number: 1208243‑50‑8
• PubChem CID: 91810664

Amino Acid Sequence & Molecular Data

• Sequence: Pyr‑Glu‑Gln‑Leu‑Glu‑Arg‑Ala‑Leu‑Asn‑Ser‑Ser‑OH (11 aa)
• Formula: C₅₁H₈₄N₁₆O₂₁
• Molecular Weight: ~1 257 Da

Structural Features

• Linear peptide engineered from the Helix B surface extracellular domain of erythropoietin (EPO) :contentReference[oaicite:2]{index=2}.
• Pyroglutamic acid (Pyr or Glp) at N‑terminus distinguishes it from other peptides :contentReference[oaicite:3]{index=3}.
• Non-erythropoietic due to selective receptor interaction with EPO/CD131 heteroreceptor :contentReference[oaicite:4]{index=4}.

Pharmacokinetic/Physical Properties

• Linear structure, water-insoluble in pure form; requires buffered aqueous solutions for solubilisation :contentReference[oaicite:5]{index=5}.

Analytical Purity & Formulation

• Typical purity ≥95–98% by HPLC in research-grade materials :contentReference[oaicite:7]{index=7}.
• Usually supplied as lyophilized powder in sterile vials, solubilized in buffered saline prior to use :contentReference[oaicite:8]{index=8}.

Receptor Interaction & Mechanism

• Binds selectively to the innate repair receptor (heterodimer of EPOR and CD131), not the canonical erythropoietic EPO receptor :contentReference[oaicite:9]{index=9}.
• Capable of antagonizing TRPV1 ion channels in peripheral neurons :contentReference[oaicite:10]{index=10}.

📚 References (Academic Sources Only)

1. Swartjes M., van Velzen M., Niesters M., et al. (2014). “ARA 290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain …” Molecular Pain. :contentReference[oaicite:11]{index=11}
2. Zhang & Zhang. (2016). “ARA 290 relieves pathophysiological pain by targeting TRPV1 channel …” Peptides. :contentReference[oaicite:12]{index=12}
3. Brines M. et al. (2014). “ARA 290, a Nonerythropoietic Peptide Engineered from Erythropoietin, Improves Metabolic Control …” Molecular Medicine. :contentReference[oaicite:13]{index=13}
4. Maarten Swartjes et al. (2014). “ARA 290, a Peptide Derived from the Tertiary Structure of Erythropoietin …” Molecular Pain. :contentReference[oaicite:14]{index=14}
5. Isca Biochemicals. “Cibinetide / ARA 290 technical data” (structure, formula, CAS, purity). :contentReference[oaicite:15]{index=15}

Keywords: ARA-290, Cibinetide.