IGF1-LR3
IGF1-LR3 1mg Restock 15/12 - Image 2

IGF1-LR3 1mg Restock 15/12

£34.90

Out of stock

  • Batch HPLC tested at 99%+ purity.
  • Store frozen long term or in fridge when ready to be used.
  • 20% off purchases of ten or more.
  • Sold for research purposes only.
  • Contact us for Wholesale Orders.

 

Download COA here: IGF1-LR3.pdf
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IGF-1 LR3

Long arginine 3-IGF-1, abbreviated as IGF-1 LR3 or LR3-IGF-1, is a syntheticprotein and lengthened analogue of human insulin-like growth factor 1 (IGF-1).[1][2]It differs from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence (“arginine 3”), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) (“long”), for a total of 83 amino acids (relative to the 70 of IGF-1).[2] The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability.[1][2] As a result, it is approximately three times more potent than IGF-1,[3] and possesses a significantly longer half-life of about 20–30 hours (relative to IGF-1’s half-life of about 12–15 hours).[4]

The amino acid sequence of IGF-1 LR3 is MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA.[5]

References
  1. Tomas FM, Lemmey AB, Read LC, Ballard FJ (1996). “Superior potency of infused IGF-I analogues which bind poorly to IGF-binding proteins is maintained when administered by injection”. J. Endocrinol. 150 (1): 77–84. doi:10.1677/joe.0.1500077. PMID 8708565.
  2. Mohan S, Baylink DJ (2002). “IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms”. J. Endocrinol. 175 (1): 19–31. doi:10.1677/joe.0.1750019. PMID 12379487.
  3. Tomas FM, Knowles SE, Owens PC, Chandler CS, Francis GL, Read LC, Ballard FJ (1992). “Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats”. Biochem. J. 282 ( Pt 1) (Pt 1): 91–7. doi:10.1042/bj2820091. PMC 1130894. PMID 1371669.
  4. von der Thüsen JH, Borensztajn KS, Moimas S, van Heiningen S, Teeling P, van Berkel TJ, Biessen EA (2011). “IGF-1 has plaque-stabilizing effects in atherosclerosis by altering vascular smooth muscle cell phenotype”. Am. J. Pathol. 178 (2): 924–34. doi:10.1016/j.ajpath.2010.10.007. PMC 3069834. PMID 21281823.
  5. Mario Thevis (13 December 2010). Mass Spectrometry in Sports Drug Testing: Characterization of Prohibited Substances and Doping Control Analytical Assays. John Wiley & Sons. pp. 252–. ISBN 978-1-118-03514-6.

Keywords: IGF-1 LR3, IGF1-LR3, Long arginine 3-IGF-1, LR3-IGF-1.

86 reviews for IGF1-LR3 1mg Restock 15/12

  1. chris watts –

    Perfect for my needs.

  2. Gemma-Lee –

    Beyond my expectations.

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    Thrilled with this purchase.

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    Love how it works.

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    A real gem.

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    This is amazing.

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    Happy with this purchase.

  8. Victoria –

    Lives up to the hype.

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    ItÕs super reliable.

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    CouldnÕt be more pleased.

  11. Sheila –

    Worth every penny..

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    Truly amazing.

  13. Jessica Pert –

    This is my go-to.

  14. Samantha M. –

    It stopped working already.

  15. Jade Thompson –

    Very practical.

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    Works perfectly as expected.

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    Just love how it works.

  18. Charlotte –

    Fast delivery and works great.

  19. Kay Sage –

    Brilliant value.

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    IÕm loving it.

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    Delivery was fast and hassle-free.

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    Fast delivery.

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    Very well built.

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    Extremely happy with my choice.

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    Love the results.

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    So pleased with this.

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    Top-notch quality.

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  31. Anonymous –

    Not impressed with the shipping speed.

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    CouldnÕt ask for more.

  33. Zoe M. –

    Works perfectly as expected.

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    So glad I found this.

  35. Hayley S. –

    IÕm not happy with it at all.

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    CanÕt live without it.

  37. Amanda –

    It didnÕt meet my expectations.

  38. Michelle Hiscutt –

    Very disappointed in the slow delivery.

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    Great performance.

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    Very effective.

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    IÕm a fan.

  45. Rhianna D. –

    Does what itÕs supposed to.

  46. Toni –

    Totally worth the price.

  47. Anonymous –

    IÕve had faster deliveries from other places.

  48. Abi Askey –

    Delivery was much slower than expected.

  49. Helen Robinson –

    Shipping was painfully slow.

  50. Viki B. –

    Not worth the wait, considering the shipping time.

  51. Bethany H. –

    Disappointed with how long it took to get here.

  52. Emma Payne –

    Really low-quality product.

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    CanÕt stop using it.

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    Best quality IÕve had.

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    Super useful.

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    Great craftsmanship.

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    Great bang for the buck.

  63. Perry Farman –

    Truly excellent.

  64. Anonymous –

    Fast delivery and works perfectly.

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    Super quick delivery, very happy.

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    Fantastic performance.

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    Amazing value for money.

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    Fantastic product.

  69. Jessica A. –

    Just awesome.

  70. Sarah Fisher –

    CouldnÕt be more pleased.

  71. Siobhan Stewart –

    Very happy with my choice.

  72. Steven Meacham –

    Arrived way earlier than I thought.

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    Quick delivery, product is amazing.

  74. Lily –

    Amazed by the quick delivery.

  75. Helen Braithwaite –

    Delivery was incredibly fast!

  76. Jeremy –

    Got here faster than anticipated.

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    Fast delivery, couldnÕt be happier.

  78. Laura P. –

    Quick shipping and amazing service.

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    Arrived so fast, couldnÕt believe it.

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  81. CHRISTOPHER HORN –

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    Excellent value for money.

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Out of stock

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

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