P-21 (PO21) 5mg

• OP Labs formerly Oxford Peptides.
• Batch HPLC tested at 99%+ purity.
• Store frozen long term or in fridge when ready to be used.
• Sold for research purposes only.
• Contact us for Wholesale Orders.

Download COA here: P-21 COA.pdf
Please note if you have a different Batch ID please contact us for the latest COA.

P-21 – Technical Information

Peptide Name:
P-21 Peptide (also referred to as NAPVSIPQ analogue or Peptide P21)

Synonyms:
P-21, P21 peptide, Activity-dependent neuroprotective protein analogue, ADNP-derived peptide

Peptide Sequence (Amino Acid):
N-Acetyl-Ser-Ala-Pro-Pro-Thr-Pro-Val-Gly-Lys-Pro-Ala-Arg (Ac-SAPPTRPVGKPAR)

Molecular Formula:
C₆₀H₁₀₂N₁₈O₁₅

Molecular Weight:
1270.6 g/mol (approximate, may vary slightly depending on formulation)

CAS Number:
No dedicated CAS number; derived and modified from ADNP-related peptides

PubChem CID:
Not listed (custom synthetic peptide, not indexed in major chemical repositories)

IUPAC Name:
Due to its peptide nature, a full IUPAC name is typically not provided for synthetic sequences of this length; designation is based on linear amino acid chain with N-terminal acetylation

Peptide Classification:
Synthetic neuropeptide; analogue of naturally occurring neuroprotective peptides derived from the Activity-Dependent Neuroprotective Protein (ADNP)

Structure Representations:
SMILES (for sequence):
CC(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N

Solubility:
Soluble in water, dilute acetic acid, and most physiological buffers

References

1. Gozes, I., et al. (2000). “NAP: A peptide derived from activity-dependent neuroprotective protein (ADNP) that provides neuroprotection and developmental regulation.” Peptides, 21(5), 745–752. https://doi.org/10.1016/S0196-9781(00)00238-1
2. Bassan, M., et al. (1999). “Activity-dependent neuroprotective protein: A novel gene essential for brain formation.” Developmental Brain Research, 118(1-2), 83–90. https://doi.org/10.1016/S0165-3806(99)00137-1
3. Frenkel, D., et al. (2001). “A novel neuroprotective therapy for Alzheimer’s disease and other neurodegenerative diseases: Activity-dependent neuroprotective protein (ADNP)-derived peptide (NAP) modulates microtubule dynamics.” Annals of the New York Academy of Sciences, 939(1), 311–318. https://doi.org/10.1111/j.1749-6632.2001.tb03644.x
4. Zusev, M., et al. (2008). “Neurotrophic and neuroprotective activities of NAPVSIPQ (NAP), an ADNP-derived peptide: Regulation of microtubule dynamics via tau and end-binding proteins.” Current Alzheimer Research, 5(5), 467–471. https://doi.org/10.2174/156720508785132341