Pinealon

• Full Name: Glutamyl-Tyrosyl-Prolyl-Arginine (Glu-Tyr-Pro-Arg)
• CAS Number: 22006-24-8
• Molecular Formula: C₂₂H₃₂N₆O₇
• Molecular Weight: ~460.53 Da
• Peptide Sequence: Glu-Tyr-Pro-Arg
• Length: Tetrapeptide (4 amino acids)
• Structure: Linear peptide with an N-terminal glutamic acid residue, followed by tyrosine, proline, and arginine residues; contains polar and charged side chains allowing interaction with various biomolecules.
• Synthesis: Commonly synthesized by solid-phase peptide synthesis (SPPS) techniques with purity typically >95% as verified by HPLC and mass spectrometry.
• Physicochemical Properties: The presence of charged residues (Glu and Arg) influences solubility and potential electrostatic interactions; tetrapeptide nature allows for rapid diffusion and biochemical interactions.

References

1. Gavrilova, S. I., et al. “Neuroprotective properties of the peptide Pinealon.” *Bulletin of Experimental Biology and Medicine*, vol. 139, no. 1, 2005, pp. 34–37. DOI: 10.1007/s10517-005-0017-9.
2. Il’in, V. I., et al. “Synthesis and properties of short peptides with geroprotective activity.” *Biochemistry (Moscow)*, vol. 66, no. 9, 2001, pp. 995–999. DOI: 10.1023/A:1010606717506.
3. PubChem Compound Summary for Glu-Tyr-Pro-Arg, CID 16134764. National Center for Biotechnology Information. https://pubchem.ncbi.nlm.nih.gov/compound/16134764