- Batch HPLC tested at 99%+ purity.
- Store frozen long term or in fridge when ready to be used.
- Sold for research purposes only.
- Contact us for Wholesale Orders.
Download COA here: Selank COA.pdf
Please note if you have a different Batch ID please contact us for the latest COA.
Selank
Selank (Russian: Cеланк) is a nootropic, anxiolytic peptide developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Selank is a heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP). It is a synthetic analogue of human tuftsin.
Selank is a synthetic analogue of the immunomodulatory peptide tuftsin; as such, it mimics many of its effects. It has been shown to modulate the expression of Interleukin-6 (IL-6) and affect the balance of T helper cell cytokines.[1] It has been shown to influence the concentration of monoamine neurotransmitters[2] and induce metabolism of serotonin.[3][4] Selank has also been found to rapidly elevate the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of rats.[5]
Selank, as well as a related peptide drug, Semax, have been found to inhibit enzymes involved in the degradation of enkephalins and other endogenous regulatory peptides, and this action may be involved in their effects.[6] It has also been found to affect the activity of carboxypeptidase H and phenylmethylsulfonylfluoride-inhibited carboxypeptidase in rat nervous system tissue.[7]
References
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Uchakina ON, Uchakin PN, Miasoedov NF, Andreeva LA, Shcherbenko VE, Mezentseva MV, et al. (2008). “[Immunomodulatory effects of selank in patients with anxiety-asthenic disorders]”. Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova. 108 (5): 71–75. PMID 18577961.
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Narkevich VB, Kudrin VS, Klodt PM, Pokrovskiĭ AA, Kozlovskaia MM, Maĭskiĭ AI, Raevskiĭ KS (2008). “[Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study]”. Eksperimental’naia i Klinicheskaia Farmakologiia. 71 (5): 8–12. PMID 19093364.
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Semenova TP, Kozlovskiĭ II, Zakharova NM, Kozlovskaia MM (August 2010). “[Experimental optimization of learning and memory processes by selank]”. Eksperimental’naia i Klinicheskaia Farmakologiia. 73 (8): 2–5. PMID 20919548.
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Semenova TP, Kozlovskiĭ II, Zakharova NM, Kozlovskaia MM (2009). “[Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA]”. Eksperimental’naia i Klinicheskaia Farmakologiia. 72(4): 6–8. PMID 19803361.
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Inozemtseva LS, Karpenko EA, Dolotov OV, Levitskaya NG, Kamensky AA, Andreeva LA, Grivennikov IA (2008). “Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo”. Doklady Biological Sciences. 421: 241–243. doi:10.1134/s0012496608040066. PMID 18841804. S2CID 40709909.
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Kost NV, Sokolov OI, Gabaeva MV, Grivennikov IA, Andreeva LA, Miasoedov NF, Zozulia AA (2001). “Semax and selank inhibit the enkephalin-degrading enzymes from human serum”. Bioorganicheskaia Khimiia (in Russian). 27 (3): 180–183. doi:10.1023/A:1011373002885. PMID 11443939. S2CID 26029820.
Keywords: Selank, Cеланк.
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The best IÕve seen.
Scott Cooksley –
Arrived quickly, exactly what I wanted.
Nicola M. –
I love how this works.
Jane Runnett –
Love this item.
Jo Kentish –
Super happy with my decision.
Sue Bennett –
IÕm blown away by the quality.
Anonymous –
Absolutely love the quality.
Jarrad Harries –
Well worth it.
Laura R. –
Had to wait ages for this.
Anonymous –
IÕve had faster deliveries from other places.
Fiona –
Just awesome.
Anonymous –
Perfect for my needs.
Linda Barnes –
Totally worth the price.
Helen Anderson –
Arrived fast, no complaints at all.
Donna H. –
Arrived so fast, very happy!
Angela S. –
Super fast shipping, very happy.
Caron Butler –
Lightning fast shipping, highly recommend.
Janet –
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abigail –
Works great.
Alice –
Beyond my expectations.
Karen Yvonne Hills –
ItÕs exactly what I needed.
Gemma –
Outstanding product.
Paula P. –
Excellent value for money.
Clare M. –
Fast shipping, really impressed.
Mary J –
Amazing quality.
Charlotte Palmer –
IÕm so impressed.
Lisa S. –
Got it delivered in record time.
Iain –
Excellent product and fast delivery.
Matthew McDermott –
Superb service, very fast delivery, as with most peptides, the effects are not acute, so can’t comment on that, but they are certainly sterile.
I have ordered multiple times since my first order, which I think says everything?
Scott –
Product is good quality customer service isn’t great