SPEND £100+ GET 20% OFF
FREE NEXT DAY DELIVERY ON £20 SPEND*
Sale!
TB-500 5mg
TB-500 5mg - Image 2
TB-500 5mg - Image 3
TB-500 5mg - Image 4
TB-500 5mg - Image 5
TB-500 5mg - Image 6
TB-500 5mg - Image 7
  1. TB-500 5mg
  2. TB-500 5mg - Image 2
  3. TB-500 5mg - Image 3
  4. TB-500 5mg - Image 4
  5. TB-500 5mg - Image 5
  6. TB-500 5mg - Image 6
  7. TB-500 5mg - Image 7

TB-500 5mg

Original price was: £21.90.Current price is: £19.90.
  • Batch HPLC tested at 99%+ purity.
  • Store frozen long term or in fridge when ready to be used.
  • Sold for research purposes only.
  • Contact us for Wholesale Orders.

 

Download COA here: TB-500 COA.pdf
Please note if you have a different Batch ID please contact us for the latest COA.

Click to Send Email

 

TB-500

TB-500 (Thymosin beta-4) is a protein that in humans is encoded by the TMSB4X gene.[1][2][3] 

The protein consists (in humans) of 43 amino acids (sequence: SDKPDMAEI EKFDKSKLKK TETQEKNPLP SKETIEQEKQ AGES) and has a molecular weight of 4921 g/mol.[4]

Thymosin-β4 is a major cellular constituent in many tissues. Its intracellular concentration may reach as high as 0.5 mM.[5] Following Thymosin α1, β4 was the second of the biologically active peptides from Thymosin Fraction 5 to be completely sequenced and synthesized.[6]

This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y (TMSB4Y).[3]

Thymosin β4 was initially perceived as a thymic hormone. However this changed when it was discovered that it forms a 1:1 complex with G (globular) actin, and is present at high concentration in a wide range of mammalian cell types.[6] When appropriate, G-actin monomers polymerize to form F (filamentous) actin, which, together with other proteins that bind to actin, comprise cellular microfilaments. Formation by G-actin of the complex with β-thymosin (= “sequestration”) opposes this.

References
  1. Gómez-Márquez J, Dosil M, Segade F, Bustelo XR, Pichel JG, Dominguez F, Freire M (Oct 1989). “Thymosin-beta 4 gene. Preliminary characterization and expression in tissues, thymic cells, and lymphocytes”. Journal of Immunology. 143 (8): 2740–4. doi:10.4049/jimmunol.143.8.2740. PMID 2677145.
  2. Lahn BT, Page DC (Oct 1997). “Functional coherence of the human Y chromosome”. Science. 278 (5338): 675–80. Bibcode:1997Sci…278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
  3. “Entrez Gene: TMSB4X thymosin, beta 4, X-linked”.
  4. “protein NP_066932”. NCBI.
  5. Hannappel E (September 2007). “beta-Thymosins”. Annals of the New York Academy of Sciences. 1112 (1): 21–37. Bibcode:2007NYASA1112…21H. doi:10.1196/annals.1415.018. PMID 17468232. S2CID 222082792.
  6. Safer D, Elzinga M, Nachmias VT (March 1991). “Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable”. J. Biol. Chem. 266 (7): 4029–32. doi:10.1016/S0021-9258(20)64278-8. PMID 1999398.

 

Keywords: TB-500, TB500, Thymosin beta-4.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

➡️ Back to Product Catalogue

0
    0
    Your Cart
    Your cart is emptyReturn to Shop
    Continue Shopping